Ozone improves oxygen metabolism increasing cellular oxygenation. Ozone is capable of inducing the release and modulation of interferons and related cytokines. Also, ozone stimulates antioxidant defense systems, counteracting the state of hyperinflammation, cytokine storm and oxidative stress, suffered by patients with COVID-19. Ozone can block the virus’s ability to replicate by balancing the cellular redox state, through the control of Nrf2.

This report presents background basic ozone science and a case report of acute bacterial infection – tick bite cellulitis – which immediately responded to ozone therapy as the sole treatment, and which fully resolved within 24-48 hours.

Ebola virus may have a very narrow window of redox infectivity capacity, which can be easily exploited with ozone therapy. Ozone therapy may be a useful modality in EVD and other viral diseases and should be immediately studied to save lives that might otherwise be lost.

This case uniquely reports a connection between endodontically infected teeth and systemic disease, and additionally presents ozone therapy as a unique therapy and immune system modulator.

This case report describes a 68-year-old woman who received bilateral artificial hips on October 27, 2015. The right hip prosthesis subsequently became septic by June 2016. Three orthopedic surgeons offered her a several month program, which included removal of the prosthesis, implantation of an antibiotic impregnated “spacer” and months of intravenous antibiotics. Instead, she sought and received intravenous ozone therapy, local joint ozone gas injection, and nutritional supplements. She quickly improved.